Chemical constituents of Lomatogonium carinthiacum and Halenia corniculata

Aodungerile; Xigurigan; Tunumula; Gang Bao; Sudabilige; Chaogebadalafu; Chenlin He; Qirigeer; Laxinamujila Bai; Shuzhen Bai

doi:10.1016/j.chmed.2022.05.001

Chemical constituents of Lomatogonium carinthiacum and Halenia corniculata

Chin Herb Med. 2022 Jul 1;14(3):459-463. doi: 10.1016/j.chmed.2022.05.001. eCollection 2022 Jul.

Authors

Aodungerile^{1

2}, Xigurigan², Tunumula², Gang Bao², Sudabilige², Chaogebadalafu², Chenlin He², Qirigeer^{1

2}, Laxinamujila Bai^{1

2}, Shuzhen Bai³

Affiliations

¹ NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), School of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China.
² College of Mongolian Medicine and Pharmacy, Inner Mongolia MinZu University, Tongliao 028000, China.
³ College of College of Chemistry and Materials Science, Inner Mongolia MinZu University, Tongliao 028000, China.

Abstract

Objective: To study the chemical constituents from traditional Chinese (Mongolian) medicine, Lomatogonium carinthiacum and Halenia corniculate.

Methods: The chemical constituents were isolated and purified by silicagel column, Sephadex LH-20, ODS and high performance liquid chromategramphy. The structures were identified by NMR and MS analysis technics.

Results: Twelve compounds were isolated and identified as isovitexin (1), Luteolin-5-O-β-D-glucoside (2), Isosaponarin (3), Luteolin-7-O-β-D-glucoside (4,7), 1,4,8-Trimethoxy-xanthone-6-O-β-D-glucoronyl-(1 → 6)O-β-Dglucoside (5), friginosideD (6), 1-hydroxy-2,3,5-trimethoxyxanthone (8), 1-hydroxy-2,3,4,5-tetramethoxyxanthone (9), 1-hydroxy-2,3,4,7-tetramethoxyxanthone(10), 1-hydroxy-2,3,4,5,7-pentamethoxyxanthone (11) and usnic acid (12).

Conclusion: Compounds 6 and 12 are obtained from L. carinthiacum and H. corniculate for the first time.

Keywords: Halenia corniculate (L.) Corneaz.; Lomatogonium carinthiacum (Wulf.) Reichb.; Mongolian medicine; bioactive compounds.