Hydrophilic competent and enhanced wet-bond strength castor oil-based bioadhesive for bone repair

Xinchang Liu; Bo Tang; Qiang Li; Wei Xiao; Xinling Wang; Haijun Xiao; Zhen Zheng

doi:10.1016/j.colsurfb.2022.112835

Hydrophilic competent and enhanced wet-bond strength castor oil-based bioadhesive for bone repair

Colloids Surf B Biointerfaces. 2022 Nov:219:112835. doi: 10.1016/j.colsurfb.2022.112835. Epub 2022 Sep 9.

Authors

Xinchang Liu¹, Bo Tang², Qiang Li¹, Wei Xiao¹, Xinling Wang¹, Haijun Xiao³, Zhen Zheng⁴

Affiliations

¹ School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
² The Third Clinical Medical College of Southern Medical University, Guangzhou 510630, China; Department of Orthopedics, Central Hospital of Fengxian District, Sixth People's Hospital of Shanghai, Shanghai 201400, China.
³ The Third Clinical Medical College of Southern Medical University, Guangzhou 510630, China; Department of Orthopedics, Central Hospital of Fengxian District, Sixth People's Hospital of Shanghai, Shanghai 201400, China. Electronic address: xiaohaijun89@126.com.
⁴ School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: zzheng@sjtu.edu.cn.

PMID: 36113225
DOI: 10.1016/j.colsurfb.2022.112835

Abstract

Bone adhesive has been proved to be a promising alternative in the clinical treatment of bone repairs. However, the problems of unsatisfying bone-bonding strength, especially the bonding of cortical bone in vivo, and blocked bone tissue recovery remain barriers to clinical reparation. Benefit from dopamine-modified castor oil synthesized by an epoxy-modification method, a porous and two-component polyurethane adhesive (PUA) was prepared to overcome the current challenges encountered. The tailored surface morphology and open porosity of the adhesive layer can be obtained to meet the requirements of bone repair by tuning the fraction of the formulation. Furthermore, the incorporation of nano-hydroxyapatite improved the mechanical properties and osteocompatibility of the material. Compared with PUA without catechol groups, the introduction of catechol groups not only increased the adhesive strength from 0.28 ± 0.05 MPa to 0.58 ± 0.06 MPa under wet conditions but also enabled the enrichment of Ca²⁺ on the adhesive surface to promote bone regeneration. Besides, the cell culture experiments also indicated that PUAs show good biocompatibility and excellent adhesion to stem cells. Given its excellent wet adhesive strength and biocompatibility, this system demonstrated potential applications in orthopedic treatment.

Keywords: Adhesion strength; Bone adhesive; Dopamine modification; Polyurethane adhesive.