Two new 22-membered macrolides from Streptomyces sp. HU210

Cheng-Hong Zhang; Huan Qi; Bing Li; Shao-Yong Zhang; Li-Qin Zhang; Ji-Dong Wang

doi:10.1038/s41429-022-00563-1

Two new 22-membered macrolides from Streptomyces sp. HU210

J Antibiot (Tokyo). 2022 Nov;75(11):650-653. doi: 10.1038/s41429-022-00563-1. Epub 2022 Sep 15.

Authors

Cheng-Hong Zhang¹, Huan Qi¹, Bing Li¹, Shao-Yong Zhang¹, Li-Qin Zhang¹, Ji-Dong Wang²

Affiliations

¹ Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou, 313000, China.
² Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou, 313000, China. 02752@zjhu.edu.cn.

PMID: 36109668
DOI: 10.1038/s41429-022-00563-1

Abstract

Two new 22-membered macrolide metabolites, phthoramycins B (1) and C (2), were isolated from the fermentation broth of Streptomyces sp. HU210. Their structures were elucidated based on extensive spectroscopic techniques including 1D, 2D NMR and HRESIMS data. Compounds 1 and 2 showed moderate cytotoxic activity against human leukemia cell line K562 and lung carcinoma cell line A549.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry
Dronabinol / analogs & derivatives
Humans
Macrolides* / chemistry
Magnetic Resonance Spectroscopy
Streptomyces* / metabolism

Substances

Anti-Bacterial Agents
Macrolides
Dronabinol
HU 211