Secondary organic aerosol formation from atmospheric reactions of anisole and associated health effects

Chunlin Li; Maria V Misovich; Michal Pardo; Zheng Fang; Alexander Laskin; Jianmin Chen; Yinon Rudich

doi:10.1016/j.chemosphere.2022.136421

Secondary organic aerosol formation from atmospheric reactions of anisole and associated health effects

Chemosphere. 2022 Dec;308(Pt 2):136421. doi: 10.1016/j.chemosphere.2022.136421. Epub 2022 Sep 12.

Authors

Chunlin Li¹, Maria V Misovich², Michal Pardo³, Zheng Fang³, Alexander Laskin², Jianmin Chen⁴, Yinon Rudich⁵

Affiliations

¹ Department of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel. Electronic address: chunlin.li@weizmann.ac.il.
² Department of Chemistry, Purdue University, West Lafayette, IN, 47907, United States.
³ Department of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel.
⁴ Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science and Engineering, Institute of Atmospheric Sciences, Fudan University, Shanghai, 200438, China.
⁵ Department of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel. Electronic address: yinon.rudich@weizmann.ac.il.

PMID: 36108757
DOI: 10.1016/j.chemosphere.2022.136421

Abstract

Anisole (methoxybenzene) represents an important marker compound of lignin pyrolysis and a starting material for many chemical products. In this study, secondary organic aerosols (SOA) formed by anisole via various atmospheric processes, including homogeneous photooxidation with varying levels of OH• and NO_x and subsequent heterogeneous NO₃• dark reactions, were investigated. The yields of anisole SOA, particle-bound organoperoxides, particle-induced oxidative potential (OP), and cytotoxicity were characterized in view of the atmospheric fate of the anisole precursor. Anisole SOA yields ranged between 0.12 and 0.35, depending on the reaction pathways and aging degrees. Chemical analysis of the SOA suggests that cleavage of the benzene ring is the main reaction channel in the photooxidation of anisole to produce low-volatility, highly oxygenated small molecules. Fresh anisole SOA from OH• photooxidation are more light-absorbing and have higher OP and organoperoxide content. The high correlation between SOA OP and organoperoxide content decreases exponentially with the degree of OH• aging. However, the contribution of organoperoxides to OP is minor (<4%), suggesting that other, non-peroxide oxidizers play a central role in anisole SOA OP. The particle-induced OP and particulate organoperoxides yield both reach a maximum value after ∼2 days' of photooxidation, implicating the potential long impact of anisole during atmospheric transport. NO_x-involved photooxidation and nighttime NO₃• reactions facilitate organic nitrate formation and enhance particle light absorption. High NO_x levels suppress anisole SOA formation and organoperoxides yield in photooxidation, with decreased aerosol OP and cellular oxidative stress. In contrast, nighttime aging significantly increases the SOA toxicity and reactive oxygen species (ROS) generation in lung cells. These dynamic properties and the toxicity of anisole SOA advocate consideration of the complicated and consecutive aging processes in depicting the fate of VOCs and assessing the related effects in the atmosphere.

Keywords: Cytotoxicity; Methoxybenzene; NO(3)• aging; Oxidative potential; Photochemical oxidation; SOA yield.

MeSH terms

Aerosols / analysis
Air Pollutants* / analysis
Anisoles / analysis
Anisoles / toxicity
Benzene / analysis
Lignin / analysis
Nitrates* / chemistry
Oxidation-Reduction
Reactive Oxygen Species / analysis

Substances

Aerosols
Air Pollutants
Anisoles
Nitrates
Reactive Oxygen Species
Lignin
anisole
Benzene