We report here the first, to the best of our knowledge, demonstration of a mid-infrared (mid-IR) fiber gas amplifier based on acetylene-filled hollow-core fibers. A quasi-all-fiber structure fiber acetylene laser in a single-pass configuration is used as a seed. The injection of the seed removes the threshold and increases the laser efficiency, which are more pronounced at high pressure. In a 3.1-m HCF filled with 2.5 mbar of acetylene, the fiber gas amplifier shows a conversion efficiency (relative to the coupled pump power) of 22.2% at 3.1 µm, which is increased by 35% compared with that without the seed. Both the seed laser and the amplifier laser have good beam quality with M2 < 1.1. It is predictable that such a fiber gas amplifier can achieve a more efficient and higher power mid-IR output for other selected molecular species compared with the single-pass structure, which is beneficial to the development of high-power mid-IR fiber gas lasers.