The role of tumor-associated macrophages in oral squamous cell carcinoma

Yiwen Xue; Xiao Song; Siyu Fan; Runzhi Deng

doi:10.3389/fphys.2022.959747

The role of tumor-associated macrophages in oral squamous cell carcinoma

Front Physiol. 2022 Aug 29:13:959747. doi: 10.3389/fphys.2022.959747. eCollection 2022.

Authors

Yiwen Xue^{1

2}, Xiao Song^{1

2}, Siyu Fan^{1

2}, Runzhi Deng¹

Affiliations

¹ Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
² Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.

Abstract

Oral squamous cell carcinoma (OSCC) is a common head and neck cancer with a high recurrence rate and a low 5-year survival rate. Tumor-associated macrophages (TAMs) are important immune cells in the tumor microenvironment, which play an important role in the progression of many tumors. This article reviews the origin, and the role of TAMs in the invasion, metastasis, angiogenesis and immunosuppression of OSCC. Therapeutic strategies targeting TAMs are also discussed in hopes of providing new ideas for the treatment of OSCC.

Keywords: OSCC; TAMs; angiogenesis; immunosuppression; invasion and metastasis.

Publication types

Review