Skip the buffet, for SPARC's sake

Lukai Zhai; Connie M Krawczyk

doi:10.1016/j.immuni.2022.08.012

Skip the buffet, for SPARC's sake

Immunity. 2022 Sep 13;55(9):1583-1585. doi: 10.1016/j.immuni.2022.08.012.

Authors

Lukai Zhai¹, Connie M Krawczyk²

Affiliations

¹ Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
² Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: connie.krawczyk@vai.org.

PMID: 36103855
DOI: 10.1016/j.immuni.2022.08.012

Abstract

Caloric restriction (CR) reduces inflammation and the incidence of chronic diseases, thereby extending healthspan and lifespan. In this issue of Immunity, Ryu et al. (2022) propose that reduction of SPARC, a matricellular protein, during CR offers beneficial effects by reducing SPARC-driven inflammatory phenotypes in macrophages.

Publication types

Comment

MeSH terms

Caloric Restriction*
Humans
Inflammation
Longevity*
Osteonectin / genetics

Substances

Osteonectin
SPARC protein, human