SARS-CoV-2 takes the bait: Exosomes as endogenous decoys

Sonja Fernbach; Benjamin G Hale

doi:10.1371/journal.pbio.3001787

SARS-CoV-2 takes the bait: Exosomes as endogenous decoys

PLoS Biol. 2022 Sep 14;20(9):e3001787. doi: 10.1371/journal.pbio.3001787. eCollection 2022 Sep.

Authors

Sonja Fernbach¹, Benjamin G Hale¹

Affiliation

¹ Institute of Medical Virology, University of Zurich, Zurich, Switzerland.

Abstract

Writing in PLOS Biology, Ching and colleagues show that ACE2-decorated exosomes are deployed as natural inhibitory decoys against SARS-CoV-2. High decoy levels correlate with improved patient outcomes, suggesting they directly help COVID-19 recovery and supporting the concept of successful future decoy-based therapies.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Angiotensin-Converting Enzyme 2
COVID-19*
Cell Line
Exosomes*
Humans
SARS-CoV-2

Substances

Angiotensin-Converting Enzyme 2

Grants and funding

Work in the BGH laboratory is funded by the Swiss National Science Foundation through grant 31003A_182464 (to BGH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.