White blood cell (WBC) detection plays a vital role in peripheral blood smear analysis. However, cell detection remains a challenging task due to multi-cell adhesion, different staining and imaging conditions. Owing to the powerful feature extraction capability of deep learning, object detection methods based on convolutional neural networks (CNNs) have been widely applied in medical image analysis. Nevertheless, the CNN training is time-consuming and inaccuracy, especially for large-scale blood smear images, where most of the images are background. To address the problem, we propose a two-stage approach that treats WBC detection as a small salient object detection task. In the first saliency detection stage, we use the Itti's visual attention model to locate the regions of interest (ROIs), based on the proposed adaptive center-surround difference (ACSD) operator. In the second WBC detection stage, the modified CenterNet model is performed on ROI sub-images to obtain a more accurate localization and classification result of each WBC. Experimental results showed that our method exceeds the performance of several existing methods on two different data sets, and achieves a state-of-the-art mAP of over 98.8%.
Keywords: CenterNet; cell detection; small salient object detection; white blood cells.
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