Advancement of cell-penetrating peptides in combating triple-negative breast cancer

Mahak Fatima; Mohammed A S Abourehab; Geeta Aggarwal; Gaurav K Jain; Amirhossein Sahebkar; Prashant Kesharwani

doi:10.1016/j.drudis.2022.103353

Advancement of cell-penetrating peptides in combating triple-negative breast cancer

Drug Discov Today. 2022 Nov;27(11):103353. doi: 10.1016/j.drudis.2022.103353. Epub 2022 Sep 12.

Authors

Mahak Fatima¹, Mohammed A S Abourehab², Geeta Aggarwal³, Gaurav K Jain³, Amirhossein Sahebkar⁴, Prashant Kesharwani⁵

Affiliations

¹ Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110 062, India.
² Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Minia University, Minia 61519, Egypt.
³ Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi 110 017, India.
⁴ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁵ Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110 062, India. Electronic address: prashantdops@gmail.com.

PMID: 36099963
DOI: 10.1016/j.drudis.2022.103353

Abstract

Extensive research efforts have been made and are still ongoing in the search for an ideal anti-cancer therapy. Almost all chemotherapeutics require a carrier or vehicle, a drug delivery system that can transport the drug specifically to the targeted cancer cells, sparing normal cells. Cell-penetrating peptides (CPPs) provide an effective and efficient pathway for the intra-cellular transportation of various bioactive molecules in several biomedical therapies. They are now well-recognized as facilitators of intracellular cargo delivery and have excellent potential for targeted anti-cancer therapy. In this review, we explain CPPs, recent progress in the development of new CPPs, and their utilization to transport cargoes such as imaging agents, chemotherapeutics, and short-interfering RNAs (siRNA) into tumor cells, contributing to the advancement of novel tumor-specific delivery systems.

Keywords: Cell-penetrating peptides; Chemotherapy; Drug delivery; Nanocarriers; Nanotechnology; Triple-negative breast cancer.

Publication types

Review