Due to their low cost, biodegradability, and ease of preparation, deep eutectic solvents (DESs) are considered promising green alternatives to conventional solvents, as exploiting green solvents has been a research focus for achieving sustainable development goals. Most DESs in published studies are hydrophilic. On the other hand, the DES's hydrophilicity restricts its practical applicability to just polar molecules, which is a vital disadvantage to this extractant. Hydrophobic DES (HDES) has been developed as a new extractant adept at extracting nonpolar inorganic and organic compounds from aqueous systems. Although there has been little research on HDESs (HDES publications account for <10% of DES), specific intriguing applications have been discovered, requiring investigation and comparisons. As a result, this review covers the applications of emerging HDES in detecting pesticide residues, food additives, contaminants in food packaging, heavy metals, separation and extraction processes in food. According to the available literature, HDESs have the potential to overcome the limitations of hydrophilic DESs and be used in a broader range of applications in food with greater efficiency, which has received little attention. HDES is expected to substitute a lot of harmful organic extractants used for analytical reasons (food chemistry) in the future. Besides, the limitations of HDES were reviewed, and future studies were provided. This will serve as a reference for green chemistry advocates and practitioners in food science who want to minimize pollution and improve efficiency and benefit from the further development of HDESs.
Keywords: biological matrices; deep eutectic solvents; extraction and separation; food additives; food safety; green chemistry; green solvents; hydrophobic deep eutectic solvents.