Insights and opportunities at the crossroads of cancer and neuroscience

Chenchen Pan; Frank Winkler

doi:10.1038/s41556-022-00978-w

Insights and opportunities at the crossroads of cancer and neuroscience

Nat Cell Biol. 2022 Oct;24(10):1454-1460. doi: 10.1038/s41556-022-00978-w. Epub 2022 Sep 12.

Authors

Chenchen Pan^{1

2}, Frank Winkler^{3

4}

Affiliations

¹ Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.
² Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
³ Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany. frank.winkler@med.uni-heidelberg.de.
⁴ Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. frank.winkler@med.uni-heidelberg.de.

PMID: 36097070
DOI: 10.1038/s41556-022-00978-w

Abstract

The biological and pathological importance of mutual interactions between the nervous system and cancer have become increasingly evident. The emerging field of cancer neuroscience aims to decipher key signalling factors of cancer-nervous system crosstalk and to exploit these modulators as targets for improved anticancer therapies. Here we discuss the key achievements in cancer neuroscience research, inspire further interactions on a variety of related research topics, and provide a roadmap for future studies.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Neoplasms* / genetics
Nervous System
Neurosciences*
Signal Transduction