Basal ganglia engagement during REM sleep movements in Parkinson's disease

Ajay K Verma; Sergio Francisco Acosta Lenis; Joshua E Aman; David Escobar Sanabria; Jing Wang; Amy Pearson; Meghan Hill; Remi Patriat; Lauren E Schrock; Scott E Cooper; Michael C Park; Noam Harel; Michael J Howell; Colum D MacKinnon; Jerrold L Vitek; Luke A Johnson

doi:10.1038/s41531-022-00382-z

Basal ganglia engagement during REM sleep movements in Parkinson's disease

NPJ Parkinsons Dis. 2022 Sep 12;8(1):116. doi: 10.1038/s41531-022-00382-z.

Authors

Ajay K Verma^#¹, Sergio Francisco Acosta Lenis^#¹, Joshua E Aman¹, David Escobar Sanabria¹, Jing Wang¹, Amy Pearson¹, Meghan Hill¹, Remi Patriat², Lauren E Schrock¹, Scott E Cooper¹, Michael C Park^{1

3}, Noam Harel^{2

3}, Michael J Howell¹, Colum D MacKinnon¹, Jerrold L Vitek¹, Luke A Johnson⁴

Affiliations

¹ Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
² Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
³ Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.
⁴ Department of Neurology, University of Minnesota, Minneapolis, MN, USA. joh03032@umn.edu.

^# Contributed equally.

Abstract

To elucidate the role of the basal ganglia during REM sleep movements in Parkinson's disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.

Abstract

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