Half the world's human population is at risk for mosquito-borne diseases. Mosquitoes rely mainly on their sense of smell to find a vertebrate blood host, nectar source, and a suitable oviposition site. Advances in neurogenetic tools have now aided our understanding of the receptors that mediate the detection of sensory cues that emanate from humans. Recent studies in the anthropophilic mosquito vectors, Aedes aegypti and Anopheles gambiae, have implicated the chemosensory ionotropic-receptor (IR) family in the detection of behaviorally relevant odors and uncovered functions beyond chemical sensing. Here, we highlight the multifunctional roles of the chemosensory ionotropic receptors in anthropophilic mosquito vectors and suggest future directions to improve our understanding of the IR family.
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