Progress on the detoxification of aflatoxin B1 using natural anti-oxidants

Xiaoxuan Wang; Tiancheng Wang; Eugenie Nepovimova; Miao Long; Wenda Wu; Kamil Kuca

doi:10.1016/j.fct.2022.113417

Progress on the detoxification of aflatoxin B1 using natural anti-oxidants

Food Chem Toxicol. 2022 Nov:169:113417. doi: 10.1016/j.fct.2022.113417. Epub 2022 Sep 9.

Authors

Xiaoxuan Wang¹, Tiancheng Wang², Eugenie Nepovimova³, Miao Long⁴, Wenda Wu⁵, Kamil Kuca⁶

Affiliations

¹ Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address: 2021240673@stu.syau.edu.cn.
² Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address: tianchengwang@syau.edu.cn.
³ Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, 50003, Czech Republic. Electronic address: eugenie.nepovimova@uhk.cz.
⁴ Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address: longmiao@syau.edu.cn.
⁵ Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, 50003, Czech Republic; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address: wuwenda@njau.edu.cn.
⁶ Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, 50003, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, 50003, Czech Republic. Electronic address: kamil.kuca@uhk.cz.

PMID: 36096290
DOI: 10.1016/j.fct.2022.113417

Abstract

Aflatoxins are toxic secondary metabolites produced by Aspergillus fungi. The most toxic among them is Aflatoxin B1 (AFB1) which is known to have genotoxic, immunotoxic, teratogenic, carcinogenic, and mutagenic toxic effects (amongst others). The mechanisms responsible for its toxicity include the induction of oxidative stress, cytotoxicity, and DNAdamage. Studies have found that natural anti-oxidants can reduce the damage that AFB1 inflicts on the body by alleviating oxidative stress and inhibiting the biotransformation of AFB1. Therefore, this review outlines the latest progress in research on the use of natural anti-oxidants as antidotes to aflatoxin poisoning and their detoxification mechanisms. It also considers the problems that may possibly arise from their use and their application prospects. Our aim is to provide a useful reference for the prevention and treatment of AFB1 poisoning.

Keywords: AFB1; Detoxification; Natural anti-oxidant.

Publication types

Review

MeSH terms

Aflatoxin B1* / metabolism
Aflatoxin B1* / poisoning
Aflatoxin B1* / toxicity
Animals
Antidotes* / pharmacology
Antioxidants* / pharmacology
Carcinogens / metabolism
Carcinogens / toxicity
Chickens
Metabolic Detoxication, Phase II*

Substances

Aflatoxin B1
Antidotes
Antioxidants
Carcinogens