Antioxidant and anti-inflammation effects of dietary phytochemicals: The Nrf2/NF-κB signalling pathway and upstream factors of Nrf2

Shujian Wu; Xiyu Liao; Zhenjun Zhu; Rui Huang; Mengfei Chen; Aohuan Huang; Jumei Zhang; Qingping Wu; Juan Wang; Yu Ding

doi:10.1016/j.phytochem.2022.113429

Antioxidant and anti-inflammation effects of dietary phytochemicals: The Nrf2/NF-κB signalling pathway and upstream factors of Nrf2

Phytochemistry. 2022 Dec:204:113429. doi: 10.1016/j.phytochem.2022.113429. Epub 2022 Sep 9.

Authors

Shujian Wu¹, Xiyu Liao¹, Zhenjun Zhu², Rui Huang¹, Mengfei Chen¹, Aohuan Huang¹, Jumei Zhang³, Qingping Wu³, Juan Wang⁴, Yu Ding⁵

Affiliations

¹ Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, Guangzhou, 510070, China; Department of Food Science and Engineering, Institute of Food Safety and Nutrition, College of Science & Engineering, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
² Department of Food Science and Engineering, Institute of Food Safety and Nutrition, College of Science & Engineering, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
³ Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, Guangzhou, 510070, China.
⁴ College of Food Science, South China Agricultural University, Guangzhou, 510070, China. Electronic address: wangjuan@scau.edu.cn.
⁵ Department of Food Science and Engineering, Institute of Food Safety and Nutrition, College of Science & Engineering, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China. Electronic address: dingyu@jnu.edu.cn.

PMID: 36096269
DOI: 10.1016/j.phytochem.2022.113429

Abstract

Oxidative stress (OS) is created by an imbalance between reactive oxygen species and antioxidant levels. OS promotes inflammation and is associated with many diseases, such as neurodegenerative disorders, diabetes, and cardiovascular disease. Nrf2 and NF-κB are critical in the cellular defence against OS and the regulators of inflammatory responses, respectively. Recent studies revealed that the Nrf2 signalling pathway interacts with the NF-κB signalling pathway in OS. More importantly, many natural compounds have long been recognized to ameliorate OS and inflammation via the Nrf2 and/or NF-κB signalling pathway. Thus, we briefly overview the potential crosstalk between Nrf2 and NF-κB and the upstream regulators of Nrf2 and review the literature on the antioxidant and anti-inflammatory effects of dietary phytochemicals (DPs) that can activate these defence systems. The aim is to provide evidence for the development of DPs into functional food for the regulation of the Nrf2/NF-κB signalling pathway by upstream regulators of Nrf2.

Keywords: Content list; Crosstalk; Dietary phytochemicals; Keap1-Nrf2; NF-κB; Oxidative stress; Upstream regulator.

Publication types

Review