Lactylation, an emerging hallmark of metabolic reprogramming: Current progress and open challenges

Xuelian Liu; Yu Zhang; Wei Li; Xin Zhou

doi:10.3389/fcell.2022.972020

Lactylation, an emerging hallmark of metabolic reprogramming: Current progress and open challenges

Front Cell Dev Biol. 2022 Aug 26:10:972020. doi: 10.3389/fcell.2022.972020. eCollection 2022.

Authors

Xuelian Liu¹, Yu Zhang², Wei Li¹, Xin Zhou^{1

3

4}

Affiliations

¹ Cancer Center, The First Hospital of Jilin University, Changchun, China.
² Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, China.
³ Cancer Research Institute of Jilin University, The First Hospital of Jilin University, Changchun, China.
⁴ International Center of Future Science, Jilin University, Changchun, China.

Abstract

Lactate, the end product of glycolysis, efficiently functions as the carbon source, signaling molecules and immune regulators. Lactylation, being regulated by lactate, has recently been confirmed as a novel contributor to epigenetic landscape, not only opening a new era for in-depth exploration of lactate metabolism but also offering key breakpoints for further functional and mechanistic research. Several studies have identified the pivotal role of protein lactylation in cell fate determination, embryonic development, inflammation, cancer, and neuropsychiatric disorders. This review summarized recent advances with respect to the discovery, the derivation, the cross-species landscape, and the diverse functions of lactylation. Further, we thoroughly discussed the discrepancies and limitations in available studies, providing optimal perspectives for future research.

Keywords: epigenetic; lactate; lactylation; metabolism; posttranslational modification.

Publication types

Review