SARS-CoV-2 with Panton-Valentine leukocidin-producing Staphylococcus aureus healthcare-associated pneumonia in the Indian Ocean

Nicolas Allou; Jérome Allyn; Nicolas Traversier; Marie Baron; Renaud Blondé; Céline Dupieux; Nathalie Coolen-Allou; Julien Jabot; Guillaume Miltgen

doi:10.1016/j.heliyon.2022.e10422

SARS-CoV-2 with Panton-Valentine leukocidin-producing Staphylococcus aureus healthcare-associated pneumonia in the Indian Ocean

Heliyon. 2022 Sep;8(9):e10422. doi: 10.1016/j.heliyon.2022.e10422. Epub 2022 Sep 6.

Authors

Nicolas Allou^{1

2}, Jérome Allyn^{1

2}, Nicolas Traversier³, Marie Baron¹, Renaud Blondé⁴, Céline Dupieux⁵, Nathalie Coolen-Allou⁶, Julien Jabot¹, Guillaume Miltgen^{3

7

8}

Affiliations

¹ Réanimation Polyvalente, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France.
² Département d'Informatique Clinique, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France.
³ Microbiologie, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France.
⁴ Réanimation Polyvalente, Centre Hospitalier Mamoudzou, Route de l'hôpital, 97600, Mamoudzou, France.
⁵ Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France.
⁶ Pneumologie, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France.
⁷ UMR PIMIT, Processus Infectieux en Milieu Insulaire Tropical, CNRS 9192, INSERM U1187, IRD 249, Université de La Réunion, 97490, Sainte-Clotilde, France.
⁸ Regional Antibiotic Therapy Center (CRAtb) of Réunion, France.

Abstract

At this time, the literature reports only one case of superinfection with Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus in a patient with severe acute respiratory distress syndrome secondary to coronavirus 2 (SARS-CoV-2) pneumonia. Here we report the first two cases of PVL-producing S. aureus healthcare-associated pneumonia in patients hospitalized for SARS-CoV-2 pneumonia in the Indian Ocean region. The two isolated strains of S. aureus were found to belong to the ST152/t355 clone, a known PVL-producing S. aureus clone that circulates in Africa and is responsible for infections imported into Europe. Our two cases reinforce the hypothesis that SARS-CoV-2 infection favors the occurrence of PVL-producing S. aureus pneumonia. Production of PVL should be searched in patients returning from the Indian Ocean region who present with severe SARS-CoV-2 pneumonia complicated by superinfection with S. aureus even in the case of late onset healthcare-associated pneumonia.

Keywords: Mayotte; Panton-valentine leukocidin; Reunion Island; SARS-CoV-2; Staphylococcus aureus.

Publication types

Case Reports