Development of Drugs with Direct Antiviral Action Based on Azaheterocyclic Systems

V N Charushin; V L Rusinov; M V Varaksin; O N Chupakhin; O P Kovtun; A A Spasov

doi:10.1134/S1019331622040104

Development of Drugs with Direct Antiviral Action Based on Azaheterocyclic Systems

Her Russ Acad Sci. 2022;92(4):505-510. doi: 10.1134/S1019331622040104. Epub 2022 Sep 6.

Authors

V N Charushin^{1

2}, V L Rusinov^{1

2}, M V Varaksin^{1

2}, O N Chupakhin^{1

2}, O P Kovtun³, A A Spasov⁴

Affiliations

¹ Postovskii Institute of Organic Synthesis (IOS), Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia.
² First President of Russia Boris Yeltsin Ural Federal University (UrFU), Yekaterinburg, Russia.
³ Ural State Medical University (UrSMU), Yekaterinburg, Russia.
⁴ Volgograd State Medical University (VSMU), Volgograd, Russia.

Abstract

This article discusses the results of studies carried out in recent years by a team of scientists from the Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, in cooperation with the First President of Russia Boris Yeltsin Ural Federal University, Ural State Medical University, Volgograd State Medical University, and other scientific and production organizations of the country to create triazavirin (riamilovir) and other direct etiotropic antiviral drugs based on azaheterocyclic derivatives.

Keywords: RNA polymerase; azoloazines; favipiravir; main protease; molnupiravir; pyrazines; pyrimidines; remdesivir; triazavirin (riamilovir); triazines.

© Pleiades Publishing, Ltd. 2022, ISSN 1019-3316, Herald of the Russian Academy of Sciences, 2022, Vol. 92, No. 4, pp. 505–510. © Pleiades Publishing, Ltd., 2022.Russian Text © The Author(s), 2022, published in Vestnik Rossiiskoi Akademii Nauk, 2022, Vol. 92, No. 8, pp. 775–780.