The molecular mechanisms of ferroptosis and its role in glioma progression and treatment

Mengyang Lu; Yuanshuai Zhou; Linjuan Sun; Shaheryar Shafi; Nafees Ahmad; Minxuan Sun; Jun Dong

doi:10.3389/fonc.2022.917537

The molecular mechanisms of ferroptosis and its role in glioma progression and treatment

Front Oncol. 2022 Aug 16:12:917537. doi: 10.3389/fonc.2022.917537. eCollection 2022.

Authors

Mengyang Lu^{1

2}, Yuanshuai Zhou², Linjuan Sun^{2

3}, Shaheryar Shafi^{2

3}, Nafees Ahmad⁴, Minxuan Sun², Jun Dong⁵

Affiliations

¹ Noncoding RNA and Cancer Lab, Faculty of Life Sciences, Shanghai University, Shanghai, China.
² Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.
³ School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
⁴ Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan.
⁵ Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Abstract

Ferroptosis is one of the programmed modes of cell death that has attracted widespread attention recently and is capable of influencing the developmental course and prognosis of many tumors. Glioma is one of the most common primary tumors of the central nervous system, but effective treatment options are very limited. Ferroptosis plays a critical role in the glioma progression, affecting tumor cell proliferation, angiogenesis, tumor necrosis, and shaping the immune-resistant tumor microenvironment. Inducing ferroptosis has emerged as an attractive strategy for glioma. In this paper, we review ferroptosis-related researches on glioma progression and treatment.

Keywords: combination therapy; ferroptosis; glioma progression; molecular mechanism; role.

Publication types

Review