Disrupted Spontaneous Neural Activity and Its Interaction With Pain and Emotion in Temporomandibular Disorders

Xiao-Fei Chen; Ping He; Kuang-Hui Xu; Yi-Han Jin; Yong Chen; Bin Wang; Xu Hu; Le Qi; Ming-Wei Wang; Jie Li

doi:10.3389/fnins.2022.941244

Disrupted Spontaneous Neural Activity and Its Interaction With Pain and Emotion in Temporomandibular Disorders

Front Neurosci. 2022 Aug 25:16:941244. doi: 10.3389/fnins.2022.941244. eCollection 2022.

Authors

Xiao-Fei Chen¹, Ping He², Kuang-Hui Xu¹, Yi-Han Jin¹, Yong Chen¹, Bin Wang², Xu Hu³, Le Qi¹, Ming-Wei Wang⁴, Jie Li¹

Affiliations

¹ Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
² Department of Orthodontics, Hangzhou Stomatological Hospital, Hangzhou, China.
³ Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
⁴ Department of Cardiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Abstract

Background and purpose: Temporomandibular disorders (TMD), especially pain-related TMD, are closely related to social and psychological factors. We aimed to measure changes in spontaneous brain activity and its related functional connectivity (FC), as well as FC characteristics within the mood-regulating circuits (MRC) in TMD patients by resting-state functional magnetic resonance imaging (RS-fMRI), and to analyze the relationship between these parameters and emotional symptoms.

Materials and methods: Twenty-one adult TMD patients and thirty demographically matched healthy controls (HCs) underwent clinical scale evaluation and RS-fMRI scanning. After processing RS-fMRI data, the values of the amplitude of low-frequency fluctuation (ALFF) between the two groups were compared. Regions with abnormal ALFF values were selected as areas of interest (ROIs) to compare the differences of whole-brain seed-based FC between groups. The FCs between regions within MRC were also analyzed and compared. In addition, the relationships between RS-fMRI characteristics and pain and mood were explored by correlation and mediation analyses.

Results: Compared with HCs, TMD patients showed increased ALFF in the right parahippocampal gyrus (PHG), the right supplementary motor area, and the bilateral precentral gyrus, with decreased ALFF in the right cerebelum_crus2. Patients showed enhanced right PHG-related FC in the vermis and posterior cingulate cortex, orbitofrontal cortex (OFC)-related FC in the striatal-frontal regions, while decreased dorsolateral prefrontal cortex-related FC in the amygdala. In TMD patients, ALFF values in the right PHG and FC values between the right PHG and the vermis were positively correlated with depressive symptoms. Abnormal FCs in the left striatal-orbitofrontal pathway were correlated with pain and depressive symptoms. More importantly, mediation analysis revealed that chronic pain mediates the relationship between FC of right PHG with vermis and depressive symptoms, and abnormal FC in the left striatal-orbitofrontal pathway can mediate the association between pain and depressive symptoms.

Conclusion: TMD patients have dysregulated spontaneous activity and FC in the default mode network, sensorimotor network and pain-related regions, as well as dysfunction of the fronto-striatal-limbic circuits. The development of negative emotions in TMD may be related to the dysfunction of components within the reward system (especially hippocampus complex, OFC, striatum) due to chronic pain.

Keywords: amplitude of low-frequency fluctuation; chronic pain; emotions; functional connectivity; resting-state fMRI; temporomandibular disorders.