Macrophage-mediated delivery of magnetic nanoparticles for enhanced magnetic resonance imaging and magnetothermal therapy of solid tumors

Fengfeng Xue; Shuntao Zhu; Qiwei Tian; Ruomeng Qin; Zerong Wang; Gang Huang; Shiping Yang

doi:10.1016/j.jcis.2022.08.186

Macrophage-mediated delivery of magnetic nanoparticles for enhanced magnetic resonance imaging and magnetothermal therapy of solid tumors

J Colloid Interface Sci. 2023 Jan;629(Pt A):554-562. doi: 10.1016/j.jcis.2022.08.186. Epub 2022 Sep 5.

Authors

Fengfeng Xue¹, Shuntao Zhu², Qiwei Tian³, Ruomeng Qin¹, Zerong Wang¹, Gang Huang⁴, Shiping Yang⁵

Affiliations

¹ Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
² Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
³ Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China. Electronic address: tianqw@sumhs.edu.cn.
⁴ Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China. Electronic address: huangg@sumhs.edu.cn.
⁵ Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China. Electronic address: shipingy@shnu.edu.cn.

PMID: 36088700
DOI: 10.1016/j.jcis.2022.08.186

Abstract

Magnetothermal therapy (MHT) has attracted significant attention due to the advantages of non-/minimal invasiveness, high efficiency, and excellent tissue penetration. However, developing small MHT agents (<50 nm) with excellent magnetothermal conversion performance and high tumor enrichment is a great challenge. Herein, a macrophage-mediated delivery of small Fe@Fe₃O₄-DHCA nanoparticles (∼14 nm) was designed for enhanced magnetic resonance imaging (MRI) and MHT of solid tumors. Based on the "Trojan horse" loading properties of the macrophages (RAW267.4 cells), the aggregation of Fe@Fe₃O₄-DHCA nanoparticles in the cells results in an enhanced MRI and magnetothermal performance in vitro. In addition, the MHT effect of RAW267.4 loaded with Fe@Fe₃O₄-DHCA in vivo is better than that of Fe@Fe₃O₄-DHCA alone, due to the tumor-targeting performance of RAW267.4 cells. This macrophage-mediated delivery provides a new strategy for the enhanced treatment effect of MHT based on Fe@Fe₃O₄-DHCA nanoparticles, and has great application potential for clinic tumor therapy.

Keywords: Fe@Fe(3)O(4); Macrophage-mediated delivery; Magnetic Resonance Imaging; Magnetothermal therapy; Tumor therapy.

MeSH terms

Cell Line, Tumor
Macrophages
Magnetic Resonance Imaging / methods
Magnetics
Magnetite Nanoparticles*
Nanoparticles*

Substances

Magnetite Nanoparticles