Pulmonary nocardiosis: Risk factors and species distribution from a high burden centre

Marilyn M Ninan; Manigandan Venkatesan; V Balaji; Priscilla Rupali; Joy S Michael

doi:10.1016/j.ijmmb.2022.08.010

Pulmonary nocardiosis: Risk factors and species distribution from a high burden centre

Indian J Med Microbiol. 2022 Oct-Dec;40(4):582-584. doi: 10.1016/j.ijmmb.2022.08.010. Epub 2022 Sep 8.

Authors

Marilyn M Ninan¹, Manigandan Venkatesan², V Balaji², Priscilla Rupali³, Joy S Michael²

Affiliations

¹ Department of Clinical Microbiology, CMC Vellore, Tamil Nadu, India. Electronic address: marilyn@cmcvellore.ac.in.
² Department of Clinical Microbiology, CMC Vellore, Tamil Nadu, India.
³ Department of Infectious Diseases, CMC Vellore, Tamil Nadu, India.

PMID: 36088197
DOI: 10.1016/j.ijmmb.2022.08.010

Abstract

Nocardiosis is a clinical and diagnostic challenge. This was a retrospective study carried out on cases of pulmonary nocardiosis presenting over 15 years. Clinical data was retrieved using the electronic patient records. Vitek MS 3.2 (MALDI TOF MS) was carried out on 22 isolates and sequencing on another 9 isolates. Of 71 patients presenting with pulmonary nocardiosis, 58 (81.6%) were on immunosuppressant therapy, 26 (46%) had a previous lung pathology, 11 (8%) were HIV associated. Disseminated disease was seen in 6 (8.4%). There were 8 (11.26%) deaths in this cohort of patients. Of 31/71 identified to species, the most common were Nocardia cyriacigeorgica (n = 11) followed by Nocardia farcinica (n = 9).

Keywords: MALDI TOF; Nocardiosis; Pulmonary; Sequencing.

MeSH terms

Humans
Immunosuppressive Agents / therapeutic use
Nocardia Infections* / diagnosis
Nocardia Infections* / drug therapy
Nocardia Infections* / epidemiology
Nocardia*
Retrospective Studies
Risk Factors
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

Immunosuppressive Agents