Hydrangea-like nanocellulose microspheres with high dye adsorption and drug encapsulation prepared by emulsion method

Hengfeng Zhu; Enwen Zhu; Yuanyuan Xie; Dongning Liu; Yang Hu; Zhuqun Shi; Chuanxi Xiong; Quanling Yang

doi:10.1016/j.carbpol.2022.119947

Hydrangea-like nanocellulose microspheres with high dye adsorption and drug encapsulation prepared by emulsion method

Carbohydr Polym. 2022 Nov 15:296:119947. doi: 10.1016/j.carbpol.2022.119947. Epub 2022 Aug 4.

Authors

Hengfeng Zhu¹, Enwen Zhu², Yuanyuan Xie², Dongning Liu², Yang Hu², Zhuqun Shi³, Chuanxi Xiong², Quanling Yang⁴

Affiliations

¹ School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China; School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China.
² School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China.
³ School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China; School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China. Electronic address: zqshi2016@whut.edu.cn.
⁴ School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China; Hainan Institute, Wuhan University of Technology, Sanya 572024, China. Electronic address: yangql@whut.edu.cn.

PMID: 36087995
DOI: 10.1016/j.carbpol.2022.119947

Abstract

Currently, microspheres with high adsorption capacity play a crucial role in dye adsorption and drug loading. In this study, 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized cellulose nanofibrils (TOCN) could be used to form nanocellulose microspheres by the emulsion method. The prepared hydrangea-like nanocellulose microspheres presented a stable three-dimensional network porous structure and exhibited excellent adsorption properties. The TOCN microspheres had a high adsorption capacity for methylene blue (MB) and methyl orange (MO) with the optimal adsorption capacity of 412.1 mg g^-1 and 286.5 mg g^-1 under neutral conditions, respectively. The TOCN microspheres displayed excellent adsorption selectivity on MB/MO mixed dyes, which could be used to selectively adsorb MB. Besides, the encapsulation rate of the positively charged drug doxorubicin hydrochloride (DOX) was as high as 93 %, and the drug loading capacity was as high as 34.5 %. Overall, our prepared nanocellulose microspheres had great potential for application in dye adsorption and drug delivery systems.

Keywords: Drug loading; Dye adsorption; Emulsification; Hydrangea; Nanocellulose microspheres.

MeSH terms

Adsorption
Coloring Agents* / chemistry
Emulsions
Hydrangea*
Methylene Blue / chemistry
Microspheres

Substances

Coloring Agents
Emulsions
Methylene Blue