On-DNA Suzuki-Miyaura Cross-Coupling

Methods Mol Biol. 2022:2541:45-48. doi: 10.1007/978-1-0716-2545-3_7.

Abstract

Suzuki-Miyaura cross-coupling is one of the most widely employed reactions in medicinal chemistry. Here we describe the efficient cross-coupling with on-DNA halide substrates using Pd(PPh3)4 as coupling catalyst.

Keywords: DNA-encoded library (DEL); Palladium; Suzuki-Miyaura cross-coupling.

MeSH terms

  • Catalysis
  • DNA*
  • Palladium*

Substances

  • Palladium
  • DNA