Efficacy of Qiancao () and Haipiaoxiao (), a traditional Chinese herb pair, on abnormal uterine bleeding in rats with incomplete abortion

Zhang Tiantian; L I Guowen; Chu Zhifeng; L I Jie; Y U Lijun; Gao Yuan; Wang Huifeng

doi:10.19852/j.cnki.jtcm.20220707.002

Efficacy of Qiancao () and Haipiaoxiao (), a traditional Chinese herb pair, on abnormal uterine bleeding in rats with incomplete abortion

J Tradit Chin Med. 2022 Oct;42(5):758-763. doi: 10.19852/j.cnki.jtcm.20220707.002.

Authors

Zhang Tiantian¹, L I Guowen², Chu Zhifeng¹, L I Jie³, Y U Lijun¹, Gao Yuan¹, Wang Huifeng¹

Affiliations

¹ Department of Pharmacy, Shanghai Songjiang Fangta Hospital of TCM, Shanghai 201600, China.
² Department of Pharmacy, Shanghai TCM-Integrated Hospital, Shanghai 200080, China.
³ Department of Traditional Chinese Medicine, Shanghai Songjiang Fangta Hospital of TCM, Shanghai 201600, China.

Abstract

Objective: To investigate the most effective weight ratio of Qiancao () and Haipiaoxiao () used to produce decoction for the treatment of abnormal uterine bleeding (AUB) in rats with incomplete abortion, and to study the possible mechanism.

Methods: The models of AUB were established by incomplete drug abortion with mifepristone and misoprostol in pregnant rats. The therapeutic effects of decoctions made by eight different weight ratios of Qiancao () and Haipiaoxiao () were observed.

Results: Statistical analysis revealed that the most effective weight ratio of Qiancao () and Haipiaoxiao () to treat AUB in this study was 2∶1.

Conclusion: The insights gained from this study would improve understanding of the mechanisms involved in the effect of Qiancao () and Haipiaoxiao () on AUB.

Keywords: Haipiaoxiao (); Qiancao (); herb pair; uterine hemorrhage; weight ratio.

MeSH terms

Abortion, Incomplete* / drug therapy
Abortion, Induced*
Animals
China
Female
Humans
Mifepristone / therapeutic use
Pregnancy
Rats
Uterine Hemorrhage / drug therapy
Uterine Hemorrhage / etiology

Substances

Mifepristone