Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells

Affiliations

• ¹ Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China.
• ² State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 200037, Shanghai, China.
• ³ Department of Surgery, University of California, San Diego, CA, USA.
• ⁴ State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 200037, Shanghai, China. jianli@ecust.edu.cn.
• ⁵ Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China. ljjia@shutcm.edu.cn.