Crystal structure and Hirshfeld surface analysis of N-(2,6-di-methyl-phen-yl)-2-[3-hy-droxy-2-oxo-3-(2-oxoprop-yl)indolin-1-yl]acetamide

Intissar Nchioua; Abdulsalam Alsubari; Joel T Mague; Youssef Ramli

doi:10.1107/S2056989022007848

Crystal structure and Hirshfeld surface analysis of N-(2,6-di-methyl-phen-yl)-2-[3-hy-droxy-2-oxo-3-(2-oxoprop-yl)indolin-1-yl]acetamide

Acta Crystallogr E Crystallogr Commun. 2022 Aug 18;78(Pt 9):922-925. doi: 10.1107/S2056989022007848. eCollection 2022 Sep 1.

Authors

Intissar Nchioua¹, Abdulsalam Alsubari², Joel T Mague³, Youssef Ramli¹

Affiliations

¹ Laboratory of Medicinal Chemistry, Drug Sciences Research Center, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.
² Laboratory of Medicinal Chemistry, Faculty of Clinical Pharmacy, 21 September University, Yemen.
³ Department of Chemistry, 8 Tulane University, New Orleans, LA 70118, USA.

Abstract

The cup-shaped conformation of the title mol-ecule, C₂₁H₂₂N₂O₄, is largely determined by an intra-molecular N-H⋯O hydrogen bond. In the crystal, double layers of mol-ecules are formed by O-H⋯O and C-H⋯O hydrogen bonds. A Hirshfeld surface analysis was performed, which confirms the regions that are active for inter-molecular inter-actions.

Keywords: Hirshfeld surface; arylacetamide; crystal structure; hydrogen bond; indole.

Grants and funding

JTM thanks Tulane University for support of the Tulane Crystallography Laboratory.