Roles of ABCA1 in cancer

Kun Wu; Longwei Zou; Xiaoyong Lei; Xiaoyan Yang

doi:10.3892/ol.2022.13469

Roles of ABCA1 in cancer

Oncol Lett. 2022 Aug 19;24(4):349. doi: 10.3892/ol.2022.13469. eCollection 2022 Oct.

Authors

Kun Wu¹, Longwei Zou¹, Xiaoyong Lei^{1

2}, Xiaoyan Yang^{1

2}

Affiliations

¹ School of Pharmacy, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
² The Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang, Hunan 421001, P.R. China.

Abstract

Studies have indicated that anticancer drugs targeting cholesterol metabolism have clinical significance. From the perspective of the mechanism of cholesterol excretion from cells, ATP-binding cassette (ABC)A1 has an essential role that cannot be ignored. ABCA1 is located on the cell membrane and able to mediate the efflux of lipids, such as intracellular cholesterol, thereby initiating reverse cholesterol transport to reduce the intracellular cholesterol level. Therefore, inducing the expression of ABCA1 may become a new breakthrough point in cancer therapy.

Keywords: ABCA1; cell proliferation; drug resistance; invasion and metastasis.

Publication types

Review

Grants and funding

This work was funded by the Hengyang City Science and Technology Planning Project (grant no. 202150063473), the Scientific Research Project of Hunan Provincial Health Commission (grant no. 202202044140), the Scientific Research Project of Hunan Provincial Education Department (grant no. 21B0438) and the Undergraduate Research-based Learning and Innovative Experimental Program of the University of South China (grant no. X202110555457).