T-Cell Responses Against Mycobacterium ulcerans and Mycobacterium tuberculosis Protein Extracts Identify Children With Buruli Ulcer Disease

J Pediatric Infect Dis Soc. 2022 Dec 28;11(12):575-577. doi: 10.1093/jpids/piac092.

Abstract

Immune-based diagnosis of Buruli ulcer disease (BUD) in children is difficult due to cross-reactivity between mycobacteria. We found that T-cell IFNγ/TNFα responses against Mycobacterium (M.) ulcerans and M. tuberculosis (PPDMulc, PPDMtub) were different between children with BUD (n = 27) and TB (n = 20) but only ratios (PPDMtub/PPDMulc) discriminated the study groups efficiently.

MeSH terms

  • Buruli Ulcer* / diagnosis
  • Buruli Ulcer* / microbiology
  • Child
  • Humans
  • Mycobacterium tuberculosis*
  • Mycobacterium ulcerans*
  • T-Lymphocytes