Combination therapy between prophylactic and therapeutic human papillomavirus (HPV) vaccines with special emphasis on implementation of nanotechnology

Asmaa Gohar; Aya A Ali; Walid F Elkhatib; Gharieb S El-Sayyad; Dounia Elfadil; Ayman M Noreddin

doi:10.1016/j.micpath.2022.105747

Combination therapy between prophylactic and therapeutic human papillomavirus (HPV) vaccines with special emphasis on implementation of nanotechnology

Microb Pathog. 2022 Oct:171:105747. doi: 10.1016/j.micpath.2022.105747. Epub 2022 Sep 5.

Authors

Asmaa Gohar¹, Aya A Ali², Walid F Elkhatib³, Gharieb S El-Sayyad⁴, Dounia Elfadil⁵, Ayman M Noreddin⁶

Affiliations

¹ Extract and Allergen Evaluation Lab., Egyptian Drug Authority (EDA), Giza, Egypt.
² Microbiology and Immunology Department, Faculty of Pharmacy, Sinai University, Egypt.
³ Microbiology and Immunology Department, Faculty of Pharmacy, Ain Shams University, African Union Organization St., Abbassia, Cairo, 11566, Egypt; Department of Microbiology and Immunology, Faculty of Pharmacy, Galala University, New Galala City, Suez, Egypt. Electronic address: walid-elkhatib@pharma.asu.edu.eg.
⁴ Department of Microbiology and Immunology, Faculty of Pharmacy, Galala University, New Galala City, Suez, Egypt; Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt. Electronic address: Gharieb.Elsayyad@gu.edu.eg.
⁵ Biology and Chemistry Department, Hassan II University of Casablanca, Morocco.
⁶ Department of Pharmacy Practice & Clinical Pharmacy, Faculty of Pharmacy, Galala University, New Galala City, Suez, Egypt; Faculty of Pharmacy, Ahram Canadian University, 6(th) of October City, Egypt.

PMID: 36064102
DOI: 10.1016/j.micpath.2022.105747

Abstract

Human papillomavirus (HPV) is the most prevalent sexually transmitted disease in the world. Even though preventive vaccines against HPV are effective, the effective treatment of HPV infections is much less satisfactory due to multi-drug resistance and secondary adverse effects. Nanotechnology was employed for the delivery of anti-cancer drugs to increase the effectiveness of the treatment and minimize the side effects. Nanodelivery of both preventive and therapeutic HPV vaccines has also been studied to boost vaccine efficacy. Overall, such developments suggest that the nanoparticle-based vaccine might emerge as the most cost-effective way to prevent and treat HPV cancer, assisted or combined with another nanotechnology-based therapy. This review focuses on the current knowledge on pathogenesis and vaccines against HPV, highlighting the current value and perspective regarding the widespread diffusion of HPV vaccines-based nanomaterials. The ongoing advancements in the design of vaccines-based nanomaterials are expanding their therapeutic roles against HPV.

Keywords: Cancer; Human papillomavirus; Nanotechnology; Pathogenesis; Therapeutic vaccine.

Publication types

Review

MeSH terms

Alphapapillomavirus*
Humans
Nanotechnology
Papillomaviridae
Papillomavirus Infections*
Papillomavirus Vaccines*

Substances

Papillomavirus Vaccines