Potential nanotechnology-based diagnostic and therapeutic approaches for Meniere's disease

Afsaneh Kashizadeh; Christopher Pastras; Navid Rabiee; Masoud Mohseni-Dargah; Payal Mukherjee; Mohsen Asadnia

doi:10.1016/j.nano.2022.102599

Potential nanotechnology-based diagnostic and therapeutic approaches for Meniere's disease

Nanomedicine. 2022 Nov:46:102599. doi: 10.1016/j.nano.2022.102599. Epub 2022 Sep 5.

Authors

Afsaneh Kashizadeh¹, Christopher Pastras², Navid Rabiee³, Masoud Mohseni-Dargah⁴, Payal Mukherjee⁵, Mohsen Asadnia⁶

Affiliations

¹ School of Electrical and Computer Engineering, Shahid Beheshti University, Tehran 1983969411, Iran.
² School of Engineering, Macquarie University, Sydney, NSW 2109, Australia; The Menière's Laboratory, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.
³ School of Engineering, Macquarie University, Sydney, NSW 2109, Australia.
⁴ School of Engineering, Macquarie University, Sydney, NSW 2109, Australia; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
⁵ RPA Institute of Academic Surgery, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
⁶ School of Engineering, Macquarie University, Sydney, NSW 2109, Australia. Electronic address: mohsen.asadnia@mq.edu.au.

PMID: 36064032
DOI: 10.1016/j.nano.2022.102599

Abstract

Meniere's disease (MD) is a progressive inner ear disorder involving recurrent and prolonged episodes or attacks of vertigo with associated symptoms, resulting in a significantly reduced quality of life for sufferers. In most cases, MD starts in one ear; however, in one-third of patients, the disorder progresses to the other ear. Unfortunately, the etiology of the disease is unknown, making the development of effective treatments difficult. Nanomaterials, including nanoparticles (NPs) and nanocarriers, offer an array of novel diagnostic and therapeutic applications related to MD. NPs have specific features such as biocompatibility, biochemical stability, targetability, and enhanced visualization using imaging tools. This paper provides a comprehensive and critical review of recent advancements in nanotechnology-based diagnostic and therapeutic approaches for MD. Furthermore, the crucial challenges adversely affecting the use of nanoparticles to treat middle ear disorders are investigated. Finally, this paper provides recommendations and future directions for improving the performances of nanomaterials on theragnostic applications of MD.

Keywords: Meniere's disease; Nano-based hybrid systems; Nanoparticles; Nanotechnology; Theragnostic applications.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Meniere Disease* / complications
Meniere Disease* / diagnosis
Meniere Disease* / therapy
Nanotechnology
Quality of Life
Vertigo / complications