A new general synthetic route to selective actinide extracting ligands for spent nuclear fuel reprocessing has been established. The amide-functionalized ligands separate Am(III) and Cm(III) from the lanthanides with high selectivities and show rapid rates of metal extraction. The ligands retain the advantages of the analogous unfunctionalized ligands derived from camphorquinone, whilst also negating their main drawback; precipitate formation when in contact with nitric acid. These studies could enable the design of improved solvent extraction processes for closing the nuclear fuel cycle.