A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery

Ni Ye; Jie Cai; Yulong Dong; Huiyao Chen; Zhiyuan Bo; Xiaogang Zhao; Mingyang Xia; Mei Han

doi:10.3389/fgene.2022.928328

A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery

Front Genet. 2022 Aug 17:13:928328. doi: 10.3389/fgene.2022.928328. eCollection 2022.

Authors

Ni Ye¹, Jie Cai², Yulong Dong³, Huiyao Chen⁴, Zhiyuan Bo⁵, Xiaogang Zhao², Mingyang Xia⁶, Mei Han¹

Affiliations

¹ Department of General Practice, The First Affiliated Hospital of Soochow University, Suzhou, China.
² Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
³ The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
⁴ Molecular Medical Center, Children's Hospital of Fudan University, Shanghai, China.
⁵ Department of Hepatobiliary Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
⁶ Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China.

Abstract

CD45, the leukocyte common antigen, is expressed on almost all cells of the immunological and hematological systems. CD45 expression is related to a variety of diseases, including leukemia and lymphoma. In this study, we analyzed the expression level of CD45 across cancers and evaluated the relationship between its expression and patient prognosis. We further integrated methylation data to explore the differences in CD45 across cancers from a multi-omics perspective. We also analyzed the relationship between CD45 expression and levels of immune cell infiltrates and immune modifiers. Our results revealed the distinct expression characteristics and prognostic value of CD45 across multiple tumors. In addition, we screened drug targets based on the immune index defined by CD45 expression and identified that GPR84 affected the proliferation of tumor cells and was associated with the inflammation caused by immunotherapy. In summary, our findings provide a comprehensive understanding of the role of CD45 in oncogenesis and its prognostic significance across cancers.

Keywords: CD45; biomarker; cancer immunotherapy; pancancer; prognosis; tumor microenvironment.