The gene regulatory role of non-coding RNAs in non-obstructive azoospermia

Front Endocrinol (Lausanne). 2022 Aug 18:13:959487. doi: 10.3389/fendo.2022.959487. eCollection 2022.

Abstract

Non-coding RNAs are classified as small non-coding RNAs, long non-coding RNAs and circular RNAs, which are involved in a variety of biological processes, including cell differentiation, proliferation, apoptosis and pathological conditions of various diseases. Many studies have shown that non-coding RNAs are related to spermatogenesis, maturation, apoptosis, function, etc. In addition, the expression of non-coding RNAs in testicular tissue and semen of patients with non-obstructive azoospermia was different. However, the role of non-coding RNAs in the pathogenesis of non-obstructive azoospermia has not been fully elucidated, and the role of non-coding RNAs in non-obstructive azoospermia is rarely reviewed. Here we summarize the research progress of non-coding RNAs in the pathogenesis of non-obstructive azoospermia.

Keywords: PIWI-interacting RNA; circular RNA; long non-coding RNA; microRNA; non-coding RNA; non-obstructive azoospermia.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azoospermia* / genetics
  • Azoospermia* / metabolism
  • Azoospermia* / pathology
  • Gene Expression Regulation
  • Humans
  • Male
  • RNA, Circular
  • RNA, Long Noncoding* / genetics
  • Spermatogenesis / genetics

Substances

  • RNA, Circular
  • RNA, Long Noncoding