Beyond keratinocyte differentiation: emerging new biology of small proline-rich proteins

Adam Zabini; Yitzhak Zimmer; Michaela Medová

doi:10.1016/j.tcb.2022.08.002

Beyond keratinocyte differentiation: emerging new biology of small proline-rich proteins

Trends Cell Biol. 2023 Jan;33(1):5-8. doi: 10.1016/j.tcb.2022.08.002. Epub 2022 Sep 1.

Authors

Adam Zabini¹, Yitzhak Zimmer¹, Michaela Medová²

Affiliations

¹ Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008 Bern, Switzerland; Department for BioMedical Research, Radiation Oncology, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
² Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008 Bern, Switzerland; Department for BioMedical Research, Radiation Oncology, University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland. Electronic address: michaela.medova@dbmr.unibe.ch.

PMID: 36057494
DOI: 10.1016/j.tcb.2022.08.002

Abstract

Small proline-rich proteins (SPRRPs) are traditionally known for their function in keratinocyte homeostasis. Recent evidence demonstrates their involvement in additional diverse physiological processes ranging from p53 signaling and direct prevention of DNA damage to bactericidal activities. We highlight these novel, intriguing roles of SPRRPs and discuss them in the context of relevant pathological conditions.

Keywords: DNA damage protection; bactericidal activity; cornified cell envelope; epithelial tissue defense; p53 signaling; reactive oxygen species; small proline-rich proteins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biology
Cornified Envelope Proline-Rich Proteins* / metabolism
Humans
Keratinocytes
Proline* / metabolism
Proteins / metabolism

Substances

Proline
Cornified Envelope Proline-Rich Proteins
Proteins