Ionones and lignans from the fresh roots of Rehmannia glutinosa

Xu Chen; Yan-Gang Cao; Ying-Jie Ren; Yan-Ling Liu; Xi-Ling Fan; Chen He; Xiang-da Li; Xin-Yi Ma; Xiao-Ke Zheng; Wei-Sheng Feng

doi:10.1016/j.phytochem.2022.113423

Ionones and lignans from the fresh roots of Rehmannia glutinosa

Phytochemistry. 2022 Nov:203:113423. doi: 10.1016/j.phytochem.2022.113423. Epub 2022 Aug 31.

Authors

Affiliations

¹ School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China,Zhengzhou, 450046, China.
² School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China,Zhengzhou, 450046, China. Electronic address: zhengxk.2006@163.com.
³ School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China,Zhengzhou, 450046, China. Electronic address: fwsh@hactcm.edu.cn.

PMID: 36055423
DOI: 10.1016/j.phytochem.2022.113423

Abstract

Nine undescribed compounds, together with 21 known components, were isolated from the fresh roots of Rehmannia glutinosa. Their structures were elucidated based on spectroscopic data analysis, and the absolute configurations of undescribed compounds were determined by comparison of their calculated and experimental electronic circular dichroic (ECD) spectra and interpretation of their optical rotation data. The α-glucosidase inhibitory effects of the isolated compounds were investigated and all of them exhibited slightly inhibitory activities.

Keywords: Rehmannia glutinosa; Scrophulariaceae; ionones; lignans; α-glucosidase inhibitory effect.

MeSH terms

Lignans* / chemistry
Norisoprenoids / chemistry
Plant Roots / chemistry
Rehmannia* / chemistry
alpha-Glucosidases

Substances

Lignans
Norisoprenoids
alpha-Glucosidases