Homozygosity for the hyperunstable hemoglobin variant Hb Agrinio (HBA2:c.89T>C) leads to severe antenatal anemia: Eight new cases in three families

Affiliations

• ¹ Pediatric Onco-Hematology Department, Reference Center on Rare Red Cell Disorders, La Timone Children's Hospital, APHM, Marseille, France.
• ² Pediatric Onco-Hematology Department, Saint-Etienne University Hospital, Saint-Etienne, France.
• ³ Biology Center "Biochimie des pathologies érythrocytaires", Lyon Est Hospital Group, Bron, France.
• ⁴ Department of Pediatrics, Nîmes University Hospital, Nîmes, France.
• ⁵ Pediatric Onco-Hematology Department, Bordeaux University Hospital, Bordeaux, France.
• ⁶ Neonatal Pediatric Care unit, Saint-Etienne University Hospital, Saint-Etienne, France.
• ⁷ Department of Hematological biology, Nîmes University Hospital, Nîmes, France.
• ⁸ Biochemistry Department, Bordeaux University Hospital, Bordeaux, France.
• ⁹ INSERM, Marseille Medical Genetics, Aix Marseille University, Marseille, France.
• ¹⁰ Department of Hematological biology, Reference Center on Rare Red Cell Disorders, Montpellier University Hospital, Montpellier, France.
• ¹¹ Molecular Genetic Laboratory, Henri Mondor University Hospital, Créteil, France.