Acute kidney injury (AKI) is a significant clinical complication with a substantial impact on morbidity and mortality, for which therapeutic options remain limited. The Hippo signaling pathway is an evolutionarily conserved pathway implicated in cell proliferation, dedifferentiation, and apoptosis via phosphorylation and inactivation of its downstream effectors Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ). Recent studies have revealed that the Hippo pathway plays a pivotal role in the pathogenesis and repair of AKI. The Hippo pathway can mediate renal dysfunction through modulation of mitochondrial apoptosis under AKI conditions. Transient activation of YAP/TAZ in the acute phase of AKI may benefit renal recovery and regeneration, whereas persistent activation of YAP/TAZ in severe AKI may lead to maladaptive repair and transition to chronic kidney disease. This review aims to summarize recent findings on the associations between the Hippo pathway and AKI and to identify new therapeutic targets and strategies for AKI.
急性肾损伤（acute kidney injury, AKI）是一种严重的临床合并症，其发病率和死亡率很高，但目前治疗手段仍然有限。Hippo信号通路是一种进化上高度保守的通路，通过磷酸化下游效应因子Yes激酶相关蛋白（Yes-associated protein, YAP）/含PDZ结合基序的转录共激活因子（transcriptional co-activator with PDZ-binding motif, TAZ）使之失活，从而参与细胞增殖、去分化及凋亡的调控。近年来的研究表明，Hippo通路在AKI发病和AKI后修复中发挥关键作用。首先，Hippo通路可以通过调节线粒体凋亡介导AKI中的肾功能不全；其次，在AKI急性期中YAP/TAZ的短暂激活可能有利于肾脏的恢复与再生，而在严重的AKI中，持续激活YAP/TAZ可能导致适应不良性修复及向慢性肾脏病（chronic kidney disease, CKD）转化。该综述旨在总结Hippo通路与AKI相关性的最新发现，并为AKI的治疗靶点和策略开辟新途径。.
Keywords: Acute kidney injury (AKI); Chronic kidney disease (CKD); Fibrosis; Hippo pathway; Maladaptive repair.