A pharmacological strategy to recapitulate exercise-induced antitumoral immunity

Amélie Rébillard; Jacques A Nunès; Alice Carrier

doi:10.1016/j.tips.2022.08.004

A pharmacological strategy to recapitulate exercise-induced antitumoral immunity

Trends Pharmacol Sci. 2022 Dec;43(12):1001-1003. doi: 10.1016/j.tips.2022.08.004. Epub 2022 Aug 30.

Authors

Amélie Rébillard¹, Jacques A Nunès², Alice Carrier³

Affiliations

¹ M2S-EA7470, University of Rennes, Rennes, France; Institut Universitaire de France (IUF), Paris, France; French Network for Nutrition and Cancer Research (NACRe network), Jouy-en-Josas, France. Electronic address: amelie.rebillard@univ-rennes2.fr.
² French Network for Nutrition and Cancer Research (NACRe network), Jouy-en-Josas, France; Aix Marseille Univ, Inserm, CNRS, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France. Electronic address: jacques.nunes@inserm.fr.
³ French Network for Nutrition and Cancer Research (NACRe network), Jouy-en-Josas, France; Aix Marseille Univ, Inserm, CNRS, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France. Electronic address: alice.carrier@inserm.fr.

PMID: 36049970
DOI: 10.1016/j.tips.2022.08.004

Abstract

The antitumor activity of exercise by means of enhanced immune activation is documented, but better identification of the underlying mechanisms is required to develop new therapeutic strategies. Recent work from the Dr Bar-Sagi group reveals that exercise engages IL-15 signaling and pharmacological activation of the IL-15/IL-15R axis mimics the exercise-driven immune cell-mediated cytotoxicity in pancreatic cancer.

Keywords: IL-15 superagonist; immunology; pancreatic cancer; physical activity.

Publication types

Comment

MeSH terms

Humans
Interleukin-15*
Signal Transduction*

Substances

Interleukin-15