Zamamiphidins B and C, Manzamine-Related Alkaloids from an Amphimedon sp. Marine Sponge Collected in Okinawa

Shin-Ichiro Kurimoto; Shoichi Suzuki; Mayumi Ueno; Jane Fromont; Jun'ichi Kobayashi; Takaaki Kubota

doi:10.1021/acs.jnatprod.2c00395

Zamamiphidins B and C, Manzamine-Related Alkaloids from an Amphimedon sp. Marine Sponge Collected in Okinawa

J Nat Prod. 2022 Sep 23;85(9):2226-2231. doi: 10.1021/acs.jnatprod.2c00395. Epub 2022 Sep 1.

Authors

Shin-Ichiro Kurimoto^{1

2}, Shoichi Suzuki¹, Mayumi Ueno¹, Jane Fromont³, Jun'ichi Kobayashi⁴, Takaaki Kubota^{1

5}

Affiliations

¹ Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
² School of Pharmacy, Showa University, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
³ Western Australian Museum, Locked Bag 49, Welshpool DC, WA 6986, Australia.
⁴ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
⁵ Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.

PMID: 36047675
DOI: 10.1021/acs.jnatprod.2c00395

Abstract

Zamamiphidins B (1) and C (2), two new manzamine-related alkaloids with an unprecedented fused diazahexacyclic ring system, were isolated from an Amphimedon sp. marine sponge collected in Okinawa. The structures of zamamiphidins B (1) and C (2) including the relative configurations were elucidated on the basis of spectroscopic data.

MeSH terms

Alkaloids* / chemistry
Alkaloids* / isolation & purification
Alkaloids* / pharmacology
Animals
Cell Line, Tumor
Molecular Structure
Porifera* / chemistry

Substances

Alkaloids