IL-33/ST2 axis in autoimmune disease

Leila Shakerian; Hanieh Kolahdooz; Mitra Garousi; Vahideh Keyvani; Ramiar Kamal Kheder; Tola Abdulsattar Faraj; Esmaeil Yazdanpanah; Seyed-Alireza Esmaeili

doi:10.1016/j.cyto.2022.156015

IL-33/ST2 axis in autoimmune disease

Cytokine. 2022 Oct:158:156015. doi: 10.1016/j.cyto.2022.156015. Epub 2022 Aug 27.

Authors

Leila Shakerian¹, Hanieh Kolahdooz², Mitra Garousi³, Vahideh Keyvani⁴, Ramiar Kamal Kheder⁵, Tola Abdulsattar Faraj⁶, Esmaeil Yazdanpanah⁷, Seyed-Alireza Esmaeili⁸

Affiliations

¹ Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
² Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Department of Internal Medicine, Faculty of Medical Sciences, Hamedan University of Medical Sciences, Hamedan, Iran.
⁴ Molecular Genetics, Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
⁵ Medical Laboratory Science Department, College of Science, University of Raparin, Rania 46012, Sulaymaniyah, Iraq; Department of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, Iraq.
⁶ Department of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, Iraq; Department of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil, Iraq.
⁷ Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁸ Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: esmaeiliar@mums.ac.ir.

PMID: 36041312
DOI: 10.1016/j.cyto.2022.156015

Abstract

Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in mast cells, basophils, eosinophils, NK cells, and T lymphocyte cells. The vital role of IL-33 as an active component gives rise to aberrant local and systemic damage which has been demonstrated in numerous inflammatory disorders and immune-mediated pathological conditions including multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis, Sjogren's syndrome, inflammatory bowel disease (IBD), etc. IL-33/ST2 axis can up-regulate pro-inflammatory cytokine release in autoimmune disease, however, in some metabolic diseases like diabetes mellitus type 1 IL-33 can be considered an anti-inflammatory cytokine. The purpose of this review is to discuss selected studies on IL-33/ST2 axis in autoimmune diseases and its potential role as a pathogenic or protective cytokine.

Keywords: Autoimmune disease; IL-33/ST2 axis; IL33; Pathogenic/ protective role; Pro-inflammatory cytokine.

Publication types

Review

MeSH terms

Autoimmune Diseases* / genetics
Autoimmune Diseases* / metabolism
Cytokines
Humans
Interleukin-1 Receptor-Like 1 Protein* / genetics
Interleukin-1 Receptor-Like 1 Protein* / metabolism
Interleukin-33* / genetics
Interleukin-33* / metabolism
Sjogren's Syndrome / genetics
Sjogren's Syndrome / metabolism

Substances

Cytokines
Interleukin-1 Receptor-Like 1 Protein
Interleukin-33