Endocardial Gene Delivery Using NOGA Catheter System

Satu Siimes; Niko Järveläinen; Henna Korpela; Seppo Ylä-Herttuala

doi:10.1007/978-1-0716-2707-5_14

Endocardial Gene Delivery Using NOGA Catheter System

Methods Mol Biol. 2022:2573:179-187. doi: 10.1007/978-1-0716-2707-5_14.

Authors

Satu Siimes^#¹, Niko Järveläinen^#¹, Henna Korpela¹, Seppo Ylä-Herttuala^{2

3}

Affiliations

¹ A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
² A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. seppo.ylaherttuala@uef.fi.
³ Heart Center and Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland. seppo.ylaherttuala@uef.fi.

^# Contributed equally.

PMID: 36040595
DOI: 10.1007/978-1-0716-2707-5_14

Abstract

NOGA/MyoStar system uses low magnetic fields and endomyocardial electrical parameters, allowing precise endomyocardial injections of therapeutic agents to ischemic yet viable myocardium which is most likely to respond to the treatment. Preclinical and clinical studies have shown that NOGA/MyoStar guided intramyocardial injections are safe, feasible and a minimally invasive way to deliver gene therapy to the heart. Here we describe how to perform electroanatomical mapping and injections to hibernating myocardium in the preclinical studies.

Keywords: Endocardial gene delivery; Gene delivery; Gene therapy; MyoStar; NOGA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catheters
Endocardium*
Genetic Therapy
Heart
Imaging, Three-Dimensional*
Myocardium