Role of private prescriptions in the long-term use of benzodiazepines and Z-drugs: A patient-related follow-up study

Pharmacoepidemiol Drug Saf. 2023 Jan;32(1):60-65. doi: 10.1002/pds.5536. Epub 2022 Sep 27.

Abstract

Purpose: To analyse (1) how often patients insured under the statutory health insurance (SHI) scheme received repeated prescriptions for benzodiazepines or Z-drugs as private prescriptions and (2) how often doctors switched from SHI prescriptions to private prescriptions and vice versa when issuing repeat prescriptions.

Methods: On basis of anonymized prescriptions from 874 ambulatory practices in Germany, we analysed the percentage of private prescriptions for Z-drugs, benzodiazepines/anxiolytics, and benzodiazepines/hypnotics and sedatives over 6 years (2014 to 2020).

Results: Of 2 200 446 prescriptions for a benzodiazepine or Z-drug, 38% were private prescriptions. In case of Z-drugs, the rate of private prescriptions was 44.1% for single prescriptions and 48.9% for refills. The difference was smaller for anxiolytics (23.3% vs. 26.0%) and, for benzodiazepine/hypnotics and sedatives, the proportion of private prescriptions for refills was even lower than for single prescriptions. In case of Z-drugs, the proportion of private prescriptions was, on average, 42.7% for the first prescription of a series of repeat prescriptions and 49.6% for the tenth prescription. The increase was smaller for anxiolytics and negligible for benzodiazepine/hypnotics and sedatives. Doctors stayed with their initial decision in more than three quarters of repeat prescriptions, be it a SHI or private prescription.

Conclusion: While we observed a large number of private prescriptions for benzodiazepines and Z-drugs, the proportion was only slightly higher for refills than for single prescriptions. Doctors do not seem to issue private prescriptions as a strategy to mask especially long-term use of these substances.

Keywords: ambulatory care; cohort studies; drug prescriptions; hypnotics and sedatives; physicians' practice patterns.

MeSH terms

  • Anti-Anxiety Agents* / therapeutic use
  • Benzodiazepines* / therapeutic use
  • Drug Prescriptions
  • Follow-Up Studies
  • Humans
  • Hypnotics and Sedatives / therapeutic use
  • Practice Patterns, Physicians'

Substances

  • Benzodiazepines
  • Anti-Anxiety Agents
  • Hypnotics and Sedatives