Background: WD repeat domain 6 (WDR6), a novel human WD-repeat gene, encodes a member of the WD repeat protein family, and its tumorigenic effect has rarely been reported so far.
Methods: Our study used Oncomine, TIMER2.0, GEPIA2, Kaplan-Meier plotter, PrognoScan, and TISIDB tools to analyze the differential expression between pan-cancer, especially lung cancer, and corresponding normal tissue, and further explore the prognostic and immunological role of WDR6 expression.
Results: Our results showed WDR6 was lower expressed in lung squamous cell carcinoma than in normal tissue, but WDR6 expression was correlated obviously with clinical stage in Lung adenocarcinoma. The overall survival, first progression, postprogression survival, and Relapse-free survival of lung cancer patients were longer in the WDR6 high-expression group than in the low-expression group. We found the expression of WDR6 significantly correlated with immune molecules, including immunomodulators, lymphocytes, and chemokines in lung cancer.
Conclusion: WDR6 can be used as a prognostic marker for lung cancer and is significantly associated with immune cell infiltration.
Keywords: WDR6; biomarker; immune infiltration; lung cancer.
© 2022 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.