Cell death affecting the progression of gastric cancer

Haoying Wang; Mengxiao Liu; Xi Zeng; Ya Zheng; Yuping Wang; Yongning Zhou

doi:10.1038/s41420-022-01161-8

Cell death affecting the progression of gastric cancer

Cell Death Discov. 2022 Aug 29;8(1):377. doi: 10.1038/s41420-022-01161-8.

Authors

Haoying Wang^#^{1

2

3}, Mengxiao Liu^#^{1

2

3}, Xi Zeng^{1

2

3}, Ya Zheng^{2

3}, Yuping Wang^{4

5}, Yongning Zhou^{6

7}

Affiliations

¹ The First Clinical Medical College, Lanzhou University, Lanzhou, China.
² Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.
³ Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.
⁴ Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. wangyuping@lzu.edu.cn.
⁵ Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China. wangyuping@lzu.edu.cn.
⁶ Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. zhouyn@lzu.edu.cn.
⁷ Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China. zhouyn@lzu.edu.cn.

^# Contributed equally.

Abstract

Gastric cancer is a gastrointestinal tumor with high morbidity and mortality rates. Several factors influence its progression, cell death being an important element. In this review, we summarized the effects of necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, and eight less common cell death modalities on gastric cancer cells and the tumor microenvironment, detailed the molecular mechanisms of various cell death and their major regulatory pathways in gastric cancer, explored the prevalence and complexity of cell death in gastric cancer progression and highlighted the potentials of cell death-related therapies in gastric cancer.

Publication types

Review