The state of the art of extracellular vesicle research in protozoan infection

Xinlei Wang; Jie Chen; Jingtong Zheng

doi:10.3389/fgene.2022.941561

The state of the art of extracellular vesicle research in protozoan infection

Front Genet. 2022 Aug 12:13:941561. doi: 10.3389/fgene.2022.941561. eCollection 2022.

Authors

Xinlei Wang¹, Jie Chen², Jingtong Zheng³

Affiliations

¹ Department of Clinical Laboratory, The Second Hospital of Jilin University, Jilin University, Changchun, China.
² Institute of Theoretical Chemistry, Jilin University, Changchun, China.
³ Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, Changchun, China.

Abstract

Protozoan diseases seriously affect the health of human beings, livestock and poultry and lead to high economic and medical costs. Extracellular vesicles (EVs) are membranous structures formed through biological processes that play important roles in immune regulation. Studies have shown that parasites transmit information to hosts through EVs to modulate host immune responses. The major roles played by EVs released from parasites involve facilitating parasitization of the host. In this review, we discuss relevant recently obtained data on EVs secreted by different kinds of protozoa, including their molecular mechanisms, and discuss the roles played by EVs in the occurrence and development of parasitic diseases.

Keywords: exosomes; extracellular vesicles; microvesicles; protozoa; protozoan diseases.

Publication types

Review