Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer

HanZheng Zhao; Xingyu Chen; WenHui Zhang; Die Cheng; Yanjie Lu; Cheng Wang; JunHu Li; LiuPing You; JiaYong Yu; WenLong Guo; YuHong Li; YueNan Huang

doi:10.3389/fsurg.2022.996844

Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer

Front Surg. 2022 Aug 12:9:996844. doi: 10.3389/fsurg.2022.996844. eCollection 2022.

Authors

HanZheng Zhao¹, Xingyu Chen², WenHui Zhang³, Die Cheng⁴, Yanjie Lu⁴, Cheng Wang¹, JunHu Li¹, LiuPing You¹, JiaYong Yu¹, WenLong Guo¹, YuHong Li⁴, YueNan Huang¹

Affiliations

¹ Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
² College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
³ Department of Pain Medicine, Harbin Medical University Cancer Hospital, Harbin, China.
⁴ Cancer Research Laboratory, Chengde Medical College, Chengde, China.

Abstract

Objective: We investigated the clinical significance of preoperative pan-immune-inflammation value (PIV) in patients with colorectal cancer (CRC).

Methods: In this retrospective study, 366 cases who underwent surgery for CRC were enrolled. Their clinical data were collected. PIV was calculated with the formula PIV = [neutrophil count (10⁹/L)× platelet count (10⁹/L) × monocyte count (10⁹/L) /lymphocyte count (10⁹/L). Patients were divided into high PIV (> median PIV) and low PIV (< median PIV) groups. The relationship between PIV and clinicopathological features of CRC was investigated. Receiver operating characteristic (ROC) curve was plotted to indicate the value of immune-inflammatory biomarkers (IIBs) in predicting the TNM stage of CRC, and the area under the curve (AUC) was calculated to evaluate the actual clinical value of IIBs. AUC > 0.5 and closer to 1 indicated the better predictive efficacy. The influencing factors of PIV in CRC were analyzed.

Results: We found that PIV was positively correlated with tumor size (r = 0.300, p < 0.05), carcinoembryonic antigen (CEA) (r = 0.214, p < 0.05) and carbohydrate antigen 125 (CA-125) (r = 0.249, p < 0.05), but negatively correlated with albumin (Alb) (r = -0.242, p < 0.05). PIV was significantly different in patients with different tumor locations (left or right), surgical methods (laparotomy versus laparoscopic surgery) (p < 0.05), and patients with different pathological T stages, N-stage and TNM stages (p < 0.05). ROC curve analysis of IIBs showed the AUC of PIV was greater than other markers when combined with CEA or carbohydrate antigen 19-9 (CA19-9). Multivariate regression analysis identified T stage, CEA, Alb, and tumor size as the independent influential factors of PIV in CRC.

Conclusion: PIV is associated with the tumor stage in patients with CRC, which may be useful in preoperative assessment of CRC.

Keywords: CA19-9; CEA; TNM stage; colorectal cancer; pan-immune-inflammation value.