Roles, detection, and visualization of neutrophil extracellular traps in acute pancreatitis

Hongxuan Li; Lingyu Zhao; Yueying Wang; Meng-Chun Zhang; Cong Qiao

doi:10.3389/fimmu.2022.974821

Roles, detection, and visualization of neutrophil extracellular traps in acute pancreatitis

Front Immunol. 2022 Aug 5:13:974821. doi: 10.3389/fimmu.2022.974821. eCollection 2022.

Authors

Hongxuan Li¹, Lingyu Zhao², Yueying Wang³, Meng-Chun Zhang⁴, Cong Qiao²

Affiliations

¹ Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
² Department of Pathology, Harbin Medical University, Harbin, China.
³ Department of Pathology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
⁴ Department of Pharmacology, Harbin Medical University, Harbin, China.

Abstract

Neutrophil extracellular traps (NETs) are produced in large quantities at the site of inflammation, and they locally capture and eliminate various pathogens. Thus, NETs quickly control the infection of pathogens in the body and play vital roles in immunity and antibacterial effects. However, evidence is accumulating that NET formation can exacerbate pancreatic tissue damage during acute pancreatitis (AP). In this review, we describe the research progress on NETs in AP and discuss the possibility of NETs as potential therapeutic targets. In addition, since the current detection and visualization methods of NET formation are not uniform and the selection of markers is still controversial, a synopsis of these issues is provided in this review.

Keywords: acute pancreatitis; citrullinated histone 3; multicolor immunofluorescence; neutrophil extracellular traps; peptidylarginine deiminase 4.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Extracellular Traps*
Humans
Neutrophils
Pancreas
Pancreatitis*