Exposure to organophosphates in association with the development of insulin resistance: Evidence from in vitro, in vivo, and clinical studies

Mathuramat Seesen; Wasana Pratchayasakul; Hiranya Pintana; Nipon Chattipakorn; Siriporn C Chattipakorn

doi:10.1016/j.fct.2022.113389

Exposure to organophosphates in association with the development of insulin resistance: Evidence from in vitro, in vivo, and clinical studies

Food Chem Toxicol. 2022 Oct:168:113389. doi: 10.1016/j.fct.2022.113389. Epub 2022 Aug 27.

Authors

Mathuramat Seesen¹, Wasana Pratchayasakul², Hiranya Pintana³, Nipon Chattipakorn², Siriporn C Chattipakorn⁴

Affiliations

¹ Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
² Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, 50200, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
³ Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, 50200, Thailand.
⁴ Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, 50200, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address: scchattipakorn@gmail.com.

PMID: 36031162
DOI: 10.1016/j.fct.2022.113389

Abstract

Insulin resistance is an underlying condition prior to the development of several diseases, including type 2 diabetes, cardiovascular diseases, cognitive impairment, and cerebrovascular complications. Organophosphates (OPs) are one of several factors thought to induce insulin resistance. Previous studies showed that the exposure to OPs pesticides induced insulin resistance through the impairment of hepatic glucose metabolism, pancreatic damage, and disruption of insulin signaling of both adipose tissues and skeletal muscles. Several studies reported possible mechanisms associated with OPs-induced insulin resistance in different models in in vivo studies including those in adult animals, obese animals, and offspring models, as well as in clinical studies. In addition, pharmacological interventions in OPs-induced insulin resistance have been previously investigated. This review aims to summarize and discuss all the evidence concerning OPs-induced insulin resistance in different models including in vitro, in vivo and clinical studies. The interventions of OPs-induced insulin resistance are also discussed. Any contradictory findings also considered. The information from this review will provide insight for possible therapeutic approaches to OPs-induced insulin resistance in the future.

Keywords: Human; Insulin resistance; Obesity; Offspring; Organophosphate.

Publication types

Review

MeSH terms

Animals
Diabetes Mellitus, Type 2* / metabolism
Glucose / metabolism
Insulin
Insulin Resistance*
Organophosphates / adverse effects
Pesticides* / toxicity

Substances

Insulin
Organophosphates
Pesticides
Glucose